Ageing, repetitive genomes and DNA damage

The mitochondrial production of reactive oxygen species is inversely proportional to longevity in animals. A key question now is, which molecules, among those that are oxidized, affect the lifespan of the organism most significantly?

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Bibliographische Detailangaben
Veröffentlicht in:	Nature reviews. Molecular cell biology 2004-01, Vol.5 (1), p.69-75
Hauptverfasser:	Lieber, Michael R, Karanjawala, Zarir E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Animals Biochemistry Biomedical and Life Sciences Cancer Research Cell Biology Cell cycle Developmental Biology DNA damage DNA Damage - genetics Genomes Humans Life Sciences Life span Longevity Metabolism Mice Mitochondria - genetics Mitochondria - physiology Mitochondrial DNA opinion-2 Oxidation Proteins Reactive Oxygen Species Repetitive Sequences, Nucleic Acid - genetics Signal transduction Stem Cells
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Beschreibung
Zusammenfassung:	The mitochondrial production of reactive oxygen species is inversely proportional to longevity in animals. A key question now is, which molecules, among those that are oxidized, affect the lifespan of the organism most significantly?
ISSN:	1471-0072 1471-0080
DOI:	10.1038/nrm1281