On the role of insulin in regulation of adenosine deaminase activity in rat tissues

After administration of insulin adenosine deaminase activity was reduced in different skeletal muscle types, the heart and the liver. On the other hand profound reduction in the plasma insulin concentration (streptozotocin diabetes) resulted in elevation of the enzyme activity in the tissues. It is...

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Veröffentlicht in:	FEBS letters 1990-10, Vol.271 (1), p.79-80
Hauptverfasser:	Rutkiewicz, Joanna, Górski, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine deaminase Adenosine Deaminase - metabolism Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Diabetes Mellitus, Experimental - enzymology Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Heart Heart - drug effects Insulin Insulin - blood Insulin - pharmacology Liver Liver - drug effects Liver - enzymology Male Muscles - drug effects Muscles - enzymology Myocardium - enzymology Rat Rats Rats, Inbred Strains Skeletal muscle Streptozocin
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Zusammenfassung:	After administration of insulin adenosine deaminase activity was reduced in different skeletal muscle types, the heart and the liver. On the other hand profound reduction in the plasma insulin concentration (streptozotocin diabetes) resulted in elevation of the enzyme activity in the tissues. It is concluded that the local concentration of adenosine may be effected by the concentration of insulin in the plasma.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(90)80376-T