Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core

A novel series of piperazines appended to a succinamide backbone were synthesized and found to have a high affinity for the melanocortin-4 receptor (IC 50s ranging from

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004, Vol.14 (2), p.377-381
Hauptverfasser:	Xi, Ning, Hale, Clarence, Kelly, Michael G., Norman, Mark H., Stec, Markian, Xu, Shimin, Baumgartner, James W., Fotsch, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - metabolism Animals Biological and medical sciences Hormones. Endocrine system Humans Medical sciences Mice Pharmacology. Drug treatments Piperazines - chemical synthesis Piperazines - metabolism Protein Binding - physiology Receptor, Melanocortin, Type 4 - agonists Receptor, Melanocortin, Type 4 - antagonists & inhibitors Receptor, Melanocortin, Type 4 - metabolism Succinates
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Beschreibung
Zusammenfassung:	A novel series of piperazines appended to a succinamide backbone were synthesized and found to have a high affinity for the melanocortin-4 receptor (IC 50s ranging from
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2003.10.056