Isolation of alpha-glusosidase inhibitors from hyssop (Hyssopus offcinalis)

alpha-Glucosidase inhibitory activity was found in aqueous methanol extracts of dried hyssop (Hyssopus officinalis) leaves. Active principles against alpha-glucosidase, prepared from rat small intestine acetone powders, were isolated and characterized. The structures of these isolated compounds were...

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Veröffentlicht in:	Phytochemistry (Oxford) 2004, Vol.65 (1), p.91-97
Hauptverfasser:	Matsuura, H, Miyazaki, H, Asakawa, C, Amano, M, Yoshihara, T, Mizutani, J
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-glucosidase Animals biochemical pathways Biological and medical sciences chemical structure enzyme inhibition enzyme inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Enzymes Fundamental and applied biological sciences. Psychology General pharmacology glucopyranosides Glucosides - chemistry Glucosides - isolation & purification Glucosides - pharmacology Glycoside Hydrolase Inhibitors herbaceous plants Hyssopus officinalis Lamiaceae - chemistry Medical sciences Metabolism Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Leaves - chemistry Plant physiology and development Rats spectral analysis Spectrometry, Mass, Fast Atom Bombardment stereochemistry
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Zusammenfassung:	alpha-Glucosidase inhibitory activity was found in aqueous methanol extracts of dried hyssop (Hyssopus officinalis) leaves. Active principles against alpha-glucosidase, prepared from rat small intestine acetone powders, were isolated and characterized. The structures of these isolated compounds were determined to be (7S, 8S)-syringoylglycerol-9-O-(6'-O-cinnamoyl)-beta-D-glucopyranoside and (7S, 8S)-syringoylglycerol 9-O-beta-D-glucopyranoside by analysis of physical and spectroscopic data (FDMS, 1H NMR, 13C NMR, HMQC, and HMBC experiments) together with chemical syntheses.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/j.phytochem.2003.10.009