Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol–polysorbate 80 mixture

Oral bioavailability of a poorly water-soluble drug was greatly enhanced by using its solid dispersion in a surface-active carrier. The weakly basic drug (p K a ∼5.5) had the highest solubility of 0.1 mg/ml at pH 1.5,

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Bibliographische Detailangaben
Veröffentlicht in:	International journal of pharmaceutics 2004-01, Vol.269 (1), p.251-258
Hauptverfasser:	Joshi, Hemant N, Tejwani, Ravindra W, Davidovich, Martha, Sahasrabudhe, Vaishali P, Jemal, Mohammed, Bathala, Mohinder S, Varia, Sailesh A, Serajuddin, Abu T.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Benzimidazoles - chemistry Benzimidazoles - pharmacokinetics Bile Acids and Salts - metabolism Bioavailability enhancement Biological and medical sciences Biological Availability Capsules Chromatography, High Pressure Liquid Crystallization Dogs General pharmacology Hydrogen-Ion Concentration In Vitro Techniques Medical sciences Pharmaceutical Solutions Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Polyethylene glycol Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Polysorbate 80 Polysorbates - chemistry Polysorbates - pharmacokinetics Poorly soluble drug Solid dispersion Solubility Surface-Active Agents - chemistry Surface-Active Agents - pharmacokinetics Water - chemistry
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Beschreibung
Zusammenfassung:	Oral bioavailability of a poorly water-soluble drug was greatly enhanced by using its solid dispersion in a surface-active carrier. The weakly basic drug (p K a ∼5.5) had the highest solubility of 0.1 mg/ml at pH 1.5,
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2003.09.002