Synthesis of galactopyranosyl amino alcohols as a new class of antitubercular and antifungal agents

The galactopyranosyl amino alcohols ( 3– 16) were synthesised by regioselective oxirane ring opening of compound 2 with variety of amines and screened for antitubercular and antifungal activities. One of the compounds ( 16) showed potent activity against Mycobacterium tuberculosis H37 Rv in vitro and also displayed activity in MDR TB. The compound ( 16) was found to be superior to ethambutol clinically used anti TB drug in in vitro screen. A series of glactopyranosyl amino alcohols have been synthesised and evaluated against Mycobacterium tuberculosis and one of them was found to be superior to ethambutol.