Cardiovascular and Renal Phenotype in Mice With One or Two Renin Genes

ABSTRACT—We compared the phenotype of two common mouse models, C-57BL/6J (C57), which carries only the Ren-1 gene, and 129/SvJ (Sv-129), with both Ren 1 and Ren-2. We hypothesized two renin gene Sv-129 would have increased blood pressure and the renin-angiotensin system would be more influential in regulating renal function compared with one renin gene mice. Sv-129 consistently had higher blood pressure than C-57, whether conscious (128 versus 108 mm Hg, P