Cell migration: Rho GTPases lead the way

Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through...

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Veröffentlicht in:	Developmental Biology 2004, Vol.265 (1), p.23-32
Hauptverfasser:	Raftopoulou, Myrto, Hall, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Cell behavior Cell migration Cell Movement - physiology Cell Polarity - physiology Cytoskeleton - metabolism Cytoskeleton - physiology Phosphatidylinositol 3-Kinases - metabolism rho GTP-Binding Proteins - physiology Rho GTPase Signal Transduction - physiology
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Zusammenfassung:	Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse functions, Rho GTPases influence many aspects of cell behavior. This review will focus specifically on their role in cell migration.
ISSN:	0012-1606 1095-564X
DOI:	10.1016/j.ydbio.2003.06.003