The Angiogenic Effect of Tissue Factor on Tumors and Wounds

Abstract We report a novel function of tissue factor (TF) as an angiogenic factor in malignant and non-malignant cells and tissue. When methylcholanthrene A-induced murine fibrosarcoma (Meth-A sarcoma) was stably transfected with mouse TF (mTF) cDNA (pXT1 expression vector), its vascularization in v...

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Veröffentlicht in:Seminars in thrombosis and hemostasis 1998-01, Vol.24 (3), p.207-210
Hauptverfasser: Nakagawa, Katsumi, Zhang, Youming, Tsuji, Hajime, Yoshizumi, Masami, Kasahara, Teruhisa, Nishimura, Hiromi, Nawroth, Peter P., Nakagawa, Masao
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Sprache:eng
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Zusammenfassung:Abstract We report a novel function of tissue factor (TF) as an angiogenic factor in malignant and non-malignant cells and tissue. When methylcholanthrene A-induced murine fibrosarcoma (Meth-A sarcoma) was stably transfected with mouse TF (mTF) cDNA (pXT1 expression vector), its vascularization in vivo was significantly enhanced, whereas TF-antisense suppressed the vascularization and tumor growth. In vitro expression of vascular endothelial growth factor (VEGF) was enhanced with stable transfection of mTF (pcDNA3 expression vector) into a mouse fibroblast cell line (NIH3T3). Moreover, in vivo topical transfection of mTF (pcDNA3) showed an enhanced vascularization and healing in a diabetic mouse wound-healing model. This effect of TF as an angiogenic factor might be useful as an antitumor therapy against hypervascular tumors or as a novel agent against delayed wound healing.
ISSN:0094-6176
1098-9064
DOI:10.1055/s-2007-995843