Growth hormone response to GHRH + GHRP-6 in type 2 diabetes during euglycemic and hyperglycemic clamp

The aim of this study was to investigate the effect of two different glucose levels on GH response to the combined administration of GHRH+GHRP-6 in patients with type 2 diabetes. GH response to i.v. bolus of GHRH+GHRP-6 (100 mcg, each) was measured in 12 male patients with type 2 diabetes (mean age: 53.9±1.59 years; BMI: 25.58±0.39 kg/m 2; mean HbA 1c: 8.7±0.42%), during a euglycemic (mean glucose: 4.92±0.08 mmol) hyperinsulinemic clamp (insulin infusion rate of 100 mU/kg/h) and a hyperglycemic clamp (mean glucose: 12.19±0.11 mmol/l). There was no difference in basal GH levels between the hyperglycemic and euglycemic clamps (2.9±0.99 mU/l versus 1.48±0.44 mU/l; P>0.05). Peak GH response to GHRH+GHRP-6 during the hyperglycemic clamp was lower than in the englycemic clamp (112.45±14.45 mU/l versus 151.06±16.87 mU/l; P