Industrial production of monoclonal antibodies and therapeutic proteins by dialysis fermentation

A novel and powerful fermentation method is reported for the large-scale growth of mammalian cells and their secreted products. The system described illustrates many of the advantages of conventional batch fermentation processes but in addition has been shown to yield cell densities in excess of 1 x...

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Veröffentlicht in:	Cytotechnology (Dordrecht) 1990-05, Vol.3 (3), p.295-299
Hauptverfasser:	Comer, M J, Kearns, M J, Wahl, J, Munster, M, Lorenz, T, Szperalski, B, Koch, S, Behrendt, U, Brunner, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - biosynthesis Biological Products - biosynthesis Biotechnology Cells, Cultured - metabolism Dialysis Fermentation Methods Mice
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A novel and powerful fermentation method is reported for the large-scale growth of mammalian cells and their secreted products. The system described illustrates many of the advantages of conventional batch fermentation processes but in addition has been shown to yield cell densities in excess of 1 x 10(7) cells/ml with concomitant increase in product concentration.
ISSN:	0920-9069 1573-0778
DOI:	10.1007/BF00365493