Signal transduction of bone morphogenetic protein receptors

Bone morphogenetic proteins (BMPs) play a crucial role during all stages of embryonic development. Although only two major signaling pathways have been characterized (the p38 and Smad pathways), the BMP signaling is complex and includes several negative feedback mechanisms. This article reviews the...

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Veröffentlicht in:	Cellular Signalling 2004-03, Vol.16 (3), p.291-299
Hauptverfasser:	Nohe, Anja, Keating, Eleonora, Knaus, Petra, Petersen, Nils O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals BMP receptors Bone Morphogenetic Protein Receptors Carrier Proteins - metabolism DNA-Binding Proteins - metabolism Feedback, Physiological Map kinase pathway MAP Kinase Signaling System Mitogen-Activated Protein Kinases - metabolism Models, Biological p38 p38 Mitogen-Activated Protein Kinases Receptors, Growth Factor - metabolism Signal Transduction Smad Smad Proteins Trans-Activators - metabolism
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Beschreibung
Zusammenfassung:	Bone morphogenetic proteins (BMPs) play a crucial role during all stages of embryonic development. Although only two major signaling pathways have been characterized (the p38 and Smad pathways), the BMP signaling is complex and includes several negative feedback mechanisms. This article reviews the current state of BMP receptor signaling and provides a summary of the crosstalk of the BMP receptor pathway with other major signaling pathways.
ISSN:	0898-6568 1873-3913
DOI:	10.1016/j.cellsig.2003.08.011