Binding of human sex hormone-binding globulin-androgen complexes to the placental syncytiotrophoblast membrane

Binding of human sex hormone-binding globulin-androgen complexes to the placental syncytiotrophoblast membrane

We have found that human SHBG complexed with androgens binds specifically to the plasma membrane of human placental syncytiotrophoblast. Apparent equilibrium association constants were 5.3· 10 11 M −1 for SHBG-testosterone complex and 1.1· 10 11 M −1 for SHBG-5α-dihydrotestosterone. Devoid of steroi...

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Veröffentlicht in:Biochemical and biophysical research communications 1990-09, Vol.171 (3), p.1279-1283
Hauptverfasser: Krupenko, Natalja I., Avvakumov, George V., Strel'chyonok, Oleg A.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Cell Membrane - metabolism
Female
Fundamental and applied biological sciences. Psychology
Hormone metabolism and regulation
Humans
Kinetics
Mammalian female genital system
Microvilli - metabolism
Placenta - metabolism
Pregnancy
Protein Binding
Sex Hormone-Binding Globulin - metabolism
Testosterone - metabolism
Trophoblasts - metabolism
Vertebrates: reproduction
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Zusammenfassung:We have found that human SHBG complexed with androgens binds specifically to the plasma membrane of human placental syncytiotrophoblast. Apparent equilibrium association constants were 5.3· 10 11 M −1 for SHBG-testosterone complex and 1.1· 10 11 M −1 for SHBG-5α-dihydrotestosterone. Devoid of steroid, SHBG did not bind to the membrane. This suggests that the specific membrane binding of SHBG-androgen complexes is a step of the mechanism of androgen action on syncytiotrophoblast.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(90)90824-7