ACE I/D gene polymorphism: presence of the ACE D allele increases the risk of coronary artery disease in younger individuals

Background: Presence of the D allele or homozygosity for the deletion (D) allele of the ACE insertion/deletion (I/D) polymorphism has been discussed as potent risk factor for coronary artery disease (CAD) and myocardial infarction (MI). Methods and results: In 2267 male Caucasians the relation of th...

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Veröffentlicht in:	Atherosclerosis 1998-07, Vol.139 (1), p.153-159
Hauptverfasser:	Gardemann, Andreas, Fink, Monika, Stricker, Jürgen, Nguyen, Quoc D, Humme, Jörg, Katz, Norbert, Tillmanns, Harald, Hehrlein, Friedrich Wilhelm, Rau, Matthias, Haberbosch, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE I/D gene polymorphism Adult Aged Aging Alleles Biological and medical sciences Cardiology. Vascular system Cardiovascular diseases Case-Control Studies Coronary Angiography Coronary Disease - etiology Coronary Disease - genetics Coronary heart disease European Continental Ancestry Group Genotype Gensini score Heart Humans Male Medical sciences Middle Aged Myocardial infarction Myocardial Infarction - genetics Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic Renin-angiotensin-aldosteron system Risk Factors
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Zusammenfassung:	Background: Presence of the D allele or homozygosity for the deletion (D) allele of the ACE insertion/deletion (I/D) polymorphism has been discussed as potent risk factor for coronary artery disease (CAD) and myocardial infarction (MI). Methods and results: In 2267 male Caucasians the relation of the ACE I/D gene polymorphism to CAD and MI were investigated. An association of the D allele to CAD was detected in younger subjects (e.g.
ISSN:	0021-9150 1879-1484
DOI:	10.1016/S0021-9150(98)00040-9