Loss of epithelial differentiation markers and acquisition of vimentin expression after xenograft with laminin-1 enhance migratory and invasive abilities of human colon cancer cells LoVo C5

Clone C5 of the the human colon adenocarcinoma LoVo cell line was subcutaneously injected with or without exogenous laminin-1 (EHS laminin) into immunosuppressed newborn rats. Cultures were initiated from lung metastases obtained with or without laminin-1 and gave rise to the C5 sublines LM and M4,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Differentiation (London) 1998-07, Vol.63 (3), p.141-150
Hauptverfasser:	Dumortier, Jérôme, Daemi, Noucha, Pourreyron, Céline, Anderson, Wena, Bellaton, Claire, Jacquier, Marie-France, Bertrand, Suzanne, Chayvialle, Jean-Alain, Remy, Lionel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Biological and medical sciences Cell Differentiation - physiology Cell Movement Collagenases - metabolism Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Dissemination Epithelial Cells - cytology Gelatinases - biosynthesis Humans Laminin - pharmacology Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Medical sciences Metalloendopeptidases - biosynthesis Neoplasm Invasiveness Neoplasm Transplantation Phenotype Rats Transplantation, Heterologous Tumor cell Tumors Vimentin - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Clone C5 of the the human colon adenocarcinoma LoVo cell line was subcutaneously injected with or without exogenous laminin-1 (EHS laminin) into immunosuppressed newborn rats. Cultures were initiated from lung metastases obtained with or without laminin-1 and gave rise to the C5 sublines LM and M4, respectively. The LM subline was mainly composed of spreading cells whereas most C5 and M4 cells remained round and aggregated. The mesenchymal marker vimentin was expressed by very rare C5 and M4 cells (
ISSN:	0301-4681 1432-0436
DOI:	10.1046/j.1432-0436.1998.6330141.x