Budding roles for myosin II on the Golgi

Myosin II—conventional myosin—has been typecast in muscle-man roles. While members of the Schwarzenegger clan from skeletal muscle have grabbed the limelight, myosin II motors in nonmuscle cells labour away in many varied and subtle roles. Recent findings show that nonmuscle myosin II, along with ot...

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Veröffentlicht in:	Trends in cell biology 1998-04, Vol.8 (4), p.138-141
Hauptverfasser:	Stow, Jennifer L, Fath, Karl R, Burgess, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Animals Golgi Apparatus - chemistry Golgi Apparatus - metabolism Golgi Apparatus - physiology Golgi appraatus Humans Models, Biological Models, Chemical myosin superfamily Myosins - chemistry Myosins - metabolism Myosins - physiology trans Golgi network vesicular traffic
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Myosin II—conventional myosin—has been typecast in muscle-man roles. While members of the Schwarzenegger clan from skeletal muscle have grabbed the limelight, myosin II motors in nonmuscle cells labour away in many varied and subtle roles. Recent findings show that nonmuscle myosin II, along with other myosins and cytoskeletal proteins, assembles on Golgi membranes. Nonmuscle myosin II associates transiently with membranes of the trans-Golgi network during the budding of a subpopulation of transport vesicles. The exact role of myosin II in vesicular trafficking is not yet understood, but its participation heralds a novel role for actin-based motors in vesicle budding.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/S0962-8924(98)01238-0