Cations and anions as modifiers of ryanodine binding to the skeletal muscle calcium release channel

Rate and equilibrium measurements of ryanodine binding to terminal cysternae fractions of heavy sarcoplasmic reticulum vesicles demonstrate that its activation by high concentrations of monovalent salts is based on neither elevated osmolarity nor ionic strength. The effect of the ions specifically d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of membrane biology 1998-08, Vol.164 (3), p.215-227
Hauptverfasser:	Hasselbach, W, Migala, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - pharmacology Animals Anions - pharmacology Cations, Monovalent - pharmacology In Vitro Techniques Kinetics Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Osmolar Concentration Rabbits Ryanodine - metabolism Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism Space life sciences
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Rate and equilibrium measurements of ryanodine binding to terminal cysternae fractions of heavy sarcoplasmic reticulum vesicles demonstrate that its activation by high concentrations of monovalent salts is based on neither elevated osmolarity nor ionic strength. The effect of the ions specifically depends on their chemical nature following the Hofmeister ion series for cations (Li+ < NH+4 < K- approximately Cs+
ISSN:	0022-2631 1432-1424
DOI:	10.1007/s002329900407