Diverging projections of the C2 and D2 olivocorticonuclear cerebellar pathways of the rat

A divergent mediolateral projection to the cerebellar nuclei of the C2 and the D2 olivocorticonuclear cerebellar pathways was found after segregate injections of a tracer (either WGA-HRP or FR or BDA) in the rostral (D2 area) or caudal side (C2 area) of the rat paraflocculus. The C2 olivary area of the cerebellar cortex sends most of its nuclear projection to the nucleus interpositus posterior (classically perceived as the nuclear target of the C2 olivocorticocerebellar pathway) and a smaller contingent of fibres to the parvocellular region of the nucleus lateralis (classically perceived as the nuclear target of the D2 olivocorticocerebellar pathway). The D2 olivary area of the cerebellar cortex sends most of its nuclear projection to the parvocellular region of the nucleus lateralis (classically perceived as the nuclear target of the D2 olivocorticocerebellar pathway) and a smaller contingent of fibres to the magnocellular region of the nucleus lateralis (classically perceived as the nuclear target of the D1 olivocorticocerebellar pathway). The lateral interaction of the D2 and the C2 olivocerebellar pathways could represent the anatomical substrate for the functional integration of different olivocerebellar compartments.