Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis

The role of the immune system in modulating atherosclerosis has recently been the subject of intensive research. Several previous authors have put forward a paradigm of the autoimmune process occurring in the vicinity of the plaque. Two recent studies have shown that immunization of rabbits with hom...

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Veröffentlicht in:Atherosclerosis 1998-05, Vol.138 (1), p.147-152
Hauptverfasser: George, Jacob, Afek, Arnon, Gilburd, Boris, Levkovitz, Hana, Shaish, Aviv, Goldberg, Iris, Kopolovic, Yuri, Wick, Georg, Shoenfeld, Yehuda, Harats, Dror
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Sprache:eng
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Zusammenfassung:The role of the immune system in modulating atherosclerosis has recently been the subject of intensive research. Several previous authors have put forward a paradigm of the autoimmune process occurring in the vicinity of the plaque. Two recent studies have shown that immunization of rabbits with homologous modified low-density lipoprotein (LDL) led to suppression of atherosclerosis. In the current study we evaluated the effects of homologous malondialdehyde (MDA)-LDL immunizations on atherogenesis in apo-E-deficient mice. Two groups of female chow-diet-fed, apo-E-deficient mice ( n=10) were either immunized with homologous MDA-LDL or with phosphate buffer saline (PBS) at 2-week intervals. The mice were sacrificed 12 weeks following the primary immunization. The MDA-LDL-immunized mice were shown to develop high titers of anti-MDA-LDL antibodies. Atherosclerosis, determined by the lesion size at the aortic sinus, was significantly suppressed in the MDA-LDL-immunized mice as compared with their littermates immunized with PBS (mean area±S.D.; 74 000±17 300 μm 2 versus 158 000±12 800 μm 2; P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(98)00015-X