Suppression of HIV-2 replication by HIV-1 gag mutants

Gag gene mutants of human immunodeficiency virus type 1 (HIV-1) were analyzed for their potentials of inhibiting the replication of wild-type (wt) HIV-2, the second AIDS virus, in a single-round of viral replication. Of twenty-two HIV-1 gag mutants examined, seven were found to efficiently interfere...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-07, Vol.248 (2), p.418-421
Hauptverfasser:	Shimano, R, Inubushi, R, Fukumori, T, Tamaki, M, Oshima, Y, Kawamura, M, Adachi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV CD4-Positive T-Lymphocytes - virology Gene Products, gag - genetics Gene Products, gag - pharmacology Genes, gag - genetics Genes, Reporter - genetics Genetic Therapy HIV Core Protein p24 - genetics HIV Core Protein p24 - pharmacology HIV-1 - genetics HIV-2 - genetics Human immunodeficiency virus 1 Human immunodeficiency virus 2 Humans Monocytes - virology Mutation - genetics Suppression, Genetic - genetics Viral Proteins - genetics Viral Proteins - pharmacology
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Beschreibung
Zusammenfassung:	Gag gene mutants of human immunodeficiency virus type 1 (HIV-1) were analyzed for their potentials of inhibiting the replication of wild-type (wt) HIV-2, the second AIDS virus, in a single-round of viral replication. Of twenty-two HIV-1 gag mutants examined, seven were found to efficiently interfere with the replication of wt HIV-2. Some mutants, which can suppress the replication of wt HIV-1, did not show this inhibitory effect. These mutants were defective at the late phase of viral replication. A mutant designated NL-C1a was demonstrated to be very effective against the replication of HIV-1 and HIV-2 in monocytic cells as well as in lymphocytic cells.
ISSN:	0006-291X
DOI:	10.1006/bbrc.1998.8975