Simaomicin (LL-D42067), a novel antibiotic from Actinomadura madurae. I. Taxonomy, fermentation and biological activity

A new antibacterial antibiotic, designated simaomicin α (LL-D42067 α) was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-D42067 was identified as a new subspecies of Actinomadura madurae. Simaom...

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Veröffentlicht in:	Journal of antibiotics 1990/09/25, Vol.43(9), pp.1059-1063
Hauptverfasser:	Maiese, W.M, Korshalla, J, Goodman, J, Torrey, M.J, Kantor, S, Labeda, D.P, Greenstein, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales Animals Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - pharmacology antibiotics antimicrobial agents antimicrobial properties chickens Chickens - parasitology coccidiosis Coccidiosis - drug therapy Coccidiosis - veterinary Coccidiostats - pharmacology Coccidiostats - therapeutic use Fermentation Gram-Positive Bacteria - drug effects Isoquinolines - pharmacology Isoquinolines - therapeutic use Male Molecular Structure Nocardiaceae - classification Nocardiaceae - metabolism Poultry Diseases - drug therapy Soil Microbiology strains
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Zusammenfassung:	A new antibacterial antibiotic, designated simaomicin α (LL-D42067 α) was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-D42067 was identified as a new subspecies of Actinomadura madurae. Simaomicin α demonstrated potent activity against Gram-positive bacteria and was active in vivo against a variety of Eimeria species causing coccidiosis in chickens.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.43.1059