Genome scan of European-American schizophrenia pedigrees: Results of the NIMH genetics initiative and millennium consortium

The Genetics Initiative of the National Institute of Mental Health (NIMH) was a multisite study that created a national repository of DNA from families informative for genetic linkage studies of schizophrenia, bipolar disorder, and Alzheimer's disease. The schizophrenia families were collected by three sites: Washington University, Harvard University, and Columbia University. This article, one in a series that describes the data collected for linkage analysis by the schizophrenia consortium, presents the results for the European‐American sample. The European‐American sample comprised 43 nuclear families and 146 subjects. Ninety‐six of the family members were considered affected by virtue of having received a DSM‐III‐R diagnosis of schizophrenia (N = 82) or schizoaffective disorder, depressed (N = 14). The families contained a total of 50 independent sib‐pairs. Using the significance threshold criteria suggested by Lander and Kruglyak [(1995): Nat Genet 241–247], no region showed statistically significant evidence for linkage; two markers on chromosome 10p showed statistical evidence suggestive of linkage using the criteria of Lander and Kruglyak [(1995): Nat Genet 241–247]: D10S1423 (nonparametric linkage (NPL) Z = 3.4, P = .0004) and its neighbor, D10S582 (NPL Z=3.2, P = .0006). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:290–295, 1998. © 1998 Wiley‐Liss, Inc.