Urine 8-Oxo-7, 8-Dihydro-2′-Deoxyguanosine vs. 5-(Hydroxymethyl) Uracil as DNA Oxidation Marker in Adriamycin-Treated Patients

We measured the base 5-(hydroxymethyl) uracil (HMUra) and the nucleoside 8-oxo-7, 8-dehydro-2′-deoxyguanosine (8-oxo-dGuo) in urine of adriamycin-treated cancer patients. Adriamycin has been shown to generate oxygen free radicals by various mechanisms. HMUra and 8-oxo-dGuo are two known lesions of D...

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Veröffentlicht in:	Free radical research 1998-01, Vol.28 (4), p.377-382
Hauptverfasser:	Faure, Henri, Mousseau, Mireille, Cadet, Jean, Guimier, Catherine, Tripier, Michelle, Hida, Hassan, Favier, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	5-(hydroxymethyl) uracil 8-dihydro-2′-deoxyguanosine 8-oxo-7 adriamycin Antibiotics, Antineoplastic - therapeutic use Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Deoxyguanosine - urine DNA - metabolism DNA damage Doxorubicin - therapeutic use Female human cancer Humans Male Neoplasms - drug therapy Neoplasms - urine Oxidation-Reduction Pentoxyl - analogs & derivatives Pentoxyl - metabolism Pentoxyl - urine Thiobarbituric Acid Reactive Substances - analysis
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