MM 47761 AND MM 49721, GLYCOPEPTIDE ANTIBIOTICS PRODUCED BY A NEW STRAIN OF AMYCOLATOPSIS ORIENTALIS: ISOLATION, PURIFICATION AND STRUCTURE DETERMINATION

MM 47761 AND MM 49721, GLYCOPEPTIDE ANTIBIOTICS PRODUCED BY A NEW STRAIN OF AMYCOLATOPSIS ORIENTALIS: ISOLATION, PURIFICATION AND STRUCTURE DETERMINATION

Two glycopeptide antibiotics MM 47761 and MM 49721 have been isolated from Amycolatopsis orientalis NCIB 12608. Fermentation conditions for their production, and methods for their isolation are described. The metabolites have been characterised by physico-chemical and biological properties and the s...

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Veröffentlicht in:Journal of antibiotics 1990/08/25, Vol.43(8), pp.931-937
Hauptverfasser: Box, STEPHEN J., ELSON, ANNA L., GILPIN, MARTIN L., WINSTANLEY, DAVID J.
Format: Artikel
Sprache:eng
Schlagworte:
Actinomycetales - metabolism
Aminoglycosides
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Chromatography, High Pressure Liquid
Chromatography, Ion Exchange
Fermentation
Fundamental and applied biological sciences. Psychology
Gram-Positive Bacteria - drug effects
Immunodiffusion
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbiology
Molecular Structure
Spectrophotometry, Ultraviolet
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Zusammenfassung:Two glycopeptide antibiotics MM 47761 and MM 49721 have been isolated from Amycolatopsis orientalis NCIB 12608. Fermentation conditions for their production, and methods for their isolation are described. The metabolites have been characterised by physico-chemical and biological properties and the structure determined by a combination of chemical degradation, COSY and NOE NMR studies. Both metabolites showed good antibacterial activity against Gram-positive organisms.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.43.931