Antineoplastic Agents. 398. Isolation and Structure Elucidation of Cephalostatins 18 and 19
Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) 1H, 13C, and 2D NMR and HRMS. B...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 1998-07, Vol.61 (7), p.955-958 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Pettit, George R Tan, Rui Xu, Jun-ping Ichihara, Yoshitatsu Williams, Michael D Boyd, Michael R |
| description | Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) 1H, 13C, and 2D NMR and HRMS. Both of these new methoxy steroidal alkaloids exhibited strong activity against the murine P-388 lymphocytic leukemia cell line (ED50 ca. 10-3 μg/mL), a mini panel of human cancer cell lines (GI50 |
| doi_str_mv | 10.1021/np9800405 |
| format | Article |
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Both of these new methoxy steroidal alkaloids exhibited strong activity against the murine P-388 lymphocytic leukemia cell line (ED50 ca. 10-3 μg/mL), a mini panel of human cancer cell lines (GI50 <10-3 μg/mL), and the U.S. National Cancer Institute's 60 human cancer cell line panel (mean panel GI50 ca. 10-9 M).</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np9800405</identifier><identifier>PMID: 9677284</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Carbohydrate Sequence ; Chordata, Nonvertebrate - chemistry ; Drug Screening Assays, Antitumor ; General pharmacology ; Humans ; Magnetic Resonance Spectroscopy ; Marine ; Mass Spectrometry ; Medical sciences ; Molecular Sequence Data ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phenazines - isolation & purification ; Phenazines - pharmacology ; Spectrometry, Mass, Fast Atom Bombardment ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet ; Spiro Compounds - isolation & purification ; Spiro Compounds - pharmacology ; Steroids ; Tumor Cells, Cultured</subject><ispartof>Journal of natural products (Washington, D.C.), 1998-07, Vol.61 (7), p.955-958</ispartof><rights>Copyright © 1998 American Chemical Society and American Society of Pharmacognosy</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a408t-c893bdfd8602d941a06768e730dfd99f749dbf4bf4a22e0831989e582d56b0b43</citedby><cites>FETCH-LOGICAL-a408t-c893bdfd8602d941a06768e730dfd99f749dbf4bf4a22e0831989e582d56b0b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np9800405$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np9800405$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2764,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2362846$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9677284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pettit, George R</creatorcontrib><creatorcontrib>Tan, Rui</creatorcontrib><creatorcontrib>Xu, Jun-ping</creatorcontrib><creatorcontrib>Ichihara, Yoshitatsu</creatorcontrib><creatorcontrib>Williams, Michael D</creatorcontrib><creatorcontrib>Boyd, Michael R</creatorcontrib><title>Antineoplastic Agents. 398. Isolation and Structure Elucidation of Cephalostatins 18 and 19</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) 1H, 13C, and 2D NMR and HRMS. Both of these new methoxy steroidal alkaloids exhibited strong activity against the murine P-388 lymphocytic leukemia cell line (ED50 ca. 10-3 μg/mL), a mini panel of human cancer cell lines (GI50 <10-3 μg/mL), and the U.S. National Cancer Institute's 60 human cancer cell line panel (mean panel GI50 ca. 10-9 M).</description><subject>Animals</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carbohydrate Sequence</subject><subject>Chordata, Nonvertebrate - chemistry</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Marine</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenazines - isolation & purification</subject><subject>Phenazines - pharmacology</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><subject>Spectrophotometry, Infrared</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Spiro Compounds - isolation & purification</subject><subject>Spiro Compounds - pharmacology</subject><subject>Steroids</subject><subject>Tumor Cells, Cultured</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9r3DAQxUVoSLdJDvkABR_aQg_ejCTr33HZpE0g0MCmvfQgZFlOnXplV5Ih-fbR1sueCoWBgXk_hvceQhcYlhgIvvSjkgAVsCO0wIxAyYGwN2gBmNOSSl69Re9ifAIACoqdoBPFhSCyWqCfK58674axNzF1tlg9Op_isqBKLovbOPQmdYMvjG-KTQqTTVNwxXU_2a6ZlaEt1m78ZfohpnzxscDyL47VGTpuTR_d-X6fou9frh_WN-Xdt6-369VdaSqQqbRS0bppG5lNN6rCBrjg0gkK-ahUKyrV1G2VxxDiQFKspHJMkobxGuqKnqJP898xDH8mF5PedtG6vjc52BS13MWmwP8LYsEUl4Jk8PMM2jDEGFyrx9BtTXjRGPSucX1oPLPv90-neuuaA7mvOOsf9rqJ1vRtMN528YARyjO181bOWBeTez7IJvzWXFDB9MP9RjN5tZHi5odWmf8488ZG_TRMweeK_2HvFR3goLc</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Pettit, George R</creator><creator>Tan, Rui</creator><creator>Xu, Jun-ping</creator><creator>Ichihara, Yoshitatsu</creator><creator>Williams, Michael D</creator><creator>Boyd, Michael R</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Antineoplastic Agents. 398. Isolation and Structure Elucidation of Cephalostatins 18 and 19</title><author>Pettit, George R ; Tan, Rui ; Xu, Jun-ping ; Ichihara, Yoshitatsu ; Williams, Michael D ; Boyd, Michael R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a408t-c893bdfd8602d941a06768e730dfd99f749dbf4bf4a22e0831989e582d56b0b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carbohydrate Sequence</topic><topic>Chordata, Nonvertebrate - chemistry</topic><topic>Drug Screening Assays, Antitumor</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Marine</topic><topic>Mass Spectrometry</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenazines - isolation & purification</topic><topic>Phenazines - pharmacology</topic><topic>Spectrometry, Mass, Fast Atom Bombardment</topic><topic>Spectrophotometry, Infrared</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Spiro Compounds - isolation & purification</topic><topic>Spiro Compounds - pharmacology</topic><topic>Steroids</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pettit, George R</creatorcontrib><creatorcontrib>Tan, Rui</creatorcontrib><creatorcontrib>Xu, Jun-ping</creatorcontrib><creatorcontrib>Ichihara, Yoshitatsu</creatorcontrib><creatorcontrib>Williams, Michael D</creatorcontrib><creatorcontrib>Boyd, Michael R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pettit, George R</au><au>Tan, Rui</au><au>Xu, Jun-ping</au><au>Ichihara, Yoshitatsu</au><au>Williams, Michael D</au><au>Boyd, Michael R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antineoplastic Agents. 398. Isolation and Structure Elucidation of Cephalostatins 18 and 19</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>61</volume><issue>7</issue><spage>955</spage><epage>958</epage><pages>955-958</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) 1H, 13C, and 2D NMR and HRMS. 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| ispartof | Journal of natural products (Washington, D.C.), 1998-07, Vol.61 (7), p.955-958 |
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| subjects | Animals Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Carbohydrate Sequence Chordata, Nonvertebrate - chemistry Drug Screening Assays, Antitumor General pharmacology Humans Magnetic Resonance Spectroscopy Marine Mass Spectrometry Medical sciences Molecular Sequence Data Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenazines - isolation & purification Phenazines - pharmacology Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Spiro Compounds - isolation & purification Spiro Compounds - pharmacology Steroids Tumor Cells, Cultured |
| title | Antineoplastic Agents. 398. Isolation and Structure Elucidation of Cephalostatins 18 and 19 |
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