Antineoplastic Agents. 398. Isolation and Structure Elucidation of Cephalostatins 18 and 19

Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) 1H, 13C, and 2D NMR and HRMS. B...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1998-07, Vol.61 (7), p.955-958
Hauptverfasser:	Pettit, George R, Tan, Rui, Xu, Jun-ping, Ichihara, Yoshitatsu, Williams, Michael D, Boyd, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Carbohydrate Sequence Chordata, Nonvertebrate - chemistry Drug Screening Assays, Antitumor General pharmacology Humans Magnetic Resonance Spectroscopy Marine Mass Spectrometry Medical sciences Molecular Sequence Data Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenazines - isolation & purification Phenazines - pharmacology Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Spiro Compounds - isolation & purification Spiro Compounds - pharmacology Steroids Tumor Cells, Cultured
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Zusammenfassung:	Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) 1H, 13C, and 2D NMR and HRMS. Both of these new methoxy steroidal alkaloids exhibited strong activity against the murine P-388 lymphocytic leukemia cell line (ED50 ca. 10-3 μg/mL), a mini panel of human cancer cell lines (GI50
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9800405