Recombinant tissue-type plasminogen activator therapy of thrombosis in 16 neonates

We report 16 cases of neonatal vascular thrombosis treated with the same protocol for recombinant tissue-type plasminogen activator infusion. Flow restoration was complete in seven patients, partial in seven, and absent in two. Safety was satisfactory provided contraindications were respected. (J Pe...

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Veröffentlicht in:	The Journal of pediatrics 1998-07, Vol.133 (1), p.137-140
Hauptverfasser:	Farnoux, Caroline, Camard, Odile, Pinquier, Didier, Hurtaud-Roux, Marie-Françoise, Sebag, Guy, Schlegel, Nicole, Beaufils, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: neonates and children. Prematurity. Sudden death Fibrinolytic Agents - therapeutic use Heparin - therapeutic use Humans Infant Infant, Newborn Intensive care medicine Medical sciences Plasminogen Activators - adverse effects Plasminogen Activators - therapeutic use Recombinant Proteins Retrospective Studies Risk Factors Thrombosis - drug therapy Thrombosis - mortality Tissue Plasminogen Activator - adverse effects Tissue Plasminogen Activator - therapeutic use Treatment Outcome
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Zusammenfassung:	We report 16 cases of neonatal vascular thrombosis treated with the same protocol for recombinant tissue-type plasminogen activator infusion. Flow restoration was complete in seven patients, partial in seven, and absent in two. Safety was satisfactory provided contraindications were respected. (J Pediatr 1998;133:137-40)
ISSN:	0022-3476 1097-6833
DOI:	10.1016/S0022-3476(98)70193-3