PRECONDITIONING IMPROVES MYOCARDIAL FUNCTION AND REFLOW, BUT NOT VASODILATOR REACTIVITY, AFTER ISCHAEMIA AND REPERFUSION IN ANAESTHETIZED DOGS

PRECONDITIONING IMPROVES MYOCARDIAL FUNCTION AND REFLOW, BUT NOT VASODILATOR REACTIVITY, AFTER ISCHAEMIA AND REPERFUSION IN ANAESTHETIZED DOGS

SUMMARY 1. The present study examines whether three cycles of brief coronary artery occlusion and reperfusion (i.e. ischaemic preconditioning; PC) can prevent vasodilator dysfunction and the impairment of myocardial reflow caused by prolonged ischaemia. Coronary blood flow, left ventricular dP/dt, s...

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Veröffentlicht in:Clinical and experimental pharmacology & physiology 1998-07, Vol.25 (7‐8), p.552-558
Hauptverfasser: Loke, Kit E., Woodman, Owen L.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine - pharmacology
Animals
Blood Pressure - drug effects
coronary blood flow
Coronary Circulation - drug effects
Coronary Circulation - physiology
Dogs
Female
Heart - drug effects
Heart - physiology
In Vitro Techniques
ischaemia
Ischemic Preconditioning, Myocardial
L-Lactate Dehydrogenase - metabolism
Male
Myocardial Infarction - pathology
Myocardial Ischemia - physiopathology
Myocardial Reperfusion
Myocardium - enzymology
Myocardium - metabolism
Nitroglycerin - pharmacology
preconditioning
Time Factors
vasodilatation
Vasodilator Agents - pharmacology
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Zusammenfassung:SUMMARY 1. The present study examines whether three cycles of brief coronary artery occlusion and reperfusion (i.e. ischaemic preconditioning; PC) can prevent vasodilator dysfunction and the impairment of myocardial reflow caused by prolonged ischaemia. Coronary blood flow, left ventricular dP/dt, systemic arterial blood pressure and heart rate were measured in open‐chest anaesthetized dogs. 2. Sixty minute occlusion of the left circumflex coronary artery (LCx) and 60 min LCx reperfusion (ISC/REP; group 1) significantly reduced resting coronary blood flow (CBF, initial 29±3mL/min; ISC/REP 20±3mL/min, P
ISSN:0305-1870
1440-1681
DOI:10.1111/j.1440-1681.1998.tb02250.x