Normalization of Blood Pressure and Renal Vascular Resistance in SHR With a Membrane-Permeable Superoxide Dismutase Mimetic: Role of Nitric Oxide

Superoxide radical (O2) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates endothelium-dependent vasodilation. The purpose of this study was to determine the role of O2 in the hypertension and renal vasoconstriction of SHR and its interaction with...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1998-07, Vol.32 (1), p.59-64
Hauptverfasser:	Schnackenberg, Christine G, Welch, William J, Wilcox, Christopher S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - administration & dosage Antioxidants - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cyclic N-Oxides - administration & dosage Cyclic N-Oxides - pharmacology Free Radical Scavengers - administration & dosage Free Radical Scavengers - pharmacology Free Radicals Kidney - drug effects Male Medical sciences NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide - physiology Rats Rats, Inbred SHR Rats, Inbred WKY Renal Circulation - drug effects Spin Labels Superoxide Dismutase - physiology Superoxides - metabolism Time Factors Vascular Resistance - drug effects
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