Normalization of Blood Pressure and Renal Vascular Resistance in SHR With a Membrane-Permeable Superoxide Dismutase Mimetic: Role of Nitric Oxide

Superoxide radical (O2) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates endothelium-dependent vasodilation. The purpose of this study was to determine the role of O2 in the hypertension and renal vasoconstriction of SHR and its interaction with...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1998-07, Vol.32 (1), p.59-64
Hauptverfasser:	Schnackenberg, Christine G, Welch, William J, Wilcox, Christopher S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - administration & dosage Antioxidants - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cyclic N-Oxides - administration & dosage Cyclic N-Oxides - pharmacology Free Radical Scavengers - administration & dosage Free Radical Scavengers - pharmacology Free Radicals Kidney - drug effects Male Medical sciences NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide - physiology Rats Rats, Inbred SHR Rats, Inbred WKY Renal Circulation - drug effects Spin Labels Superoxide Dismutase - physiology Superoxides - metabolism Time Factors Vascular Resistance - drug effects
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Zusammenfassung:	Superoxide radical (O2) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates endothelium-dependent vasodilation. The purpose of this study was to determine the role of O2 in the hypertension and renal vasoconstriction of SHR and its interaction with nitric oxide (NO). Baseline mean arterial pressure (MAP) and renal vascular resistance were markedly elevated in SHR (n=6) compared with Wistar-Kyoto rats (WKY; n=6) (145 +/- 4 versus 118 +/- 4 mm Hg, P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.32.1.59