Beneficial Effect of Atrial Natriuretic Peptide on Pulmonary Gas Exchange in Patients With Acute Lung Injury

The purpose of this study was to investigate the effect of IV infusion of atrial natriuretic peptide (ANP) on hemodynamics, pulmonary gas exchange, and urine volume during mechanical ventilation with positive end-expiratory pressure (PEEP) in patients with acute lung injury. Prospective, randomized, comparable study. ICU of a university hospital. Forty patients with moderate acute lung injury (lung injury score ≥2.0) who required mechanical ventilation with PEEP were studied. The patients were randomly divided into two groups: ANP group (n=20) and control group (n=20). The ANP group received genetic recombination α-human ANP (carperitide) at the rate of 0.1 μg/kg/min for 24 h. The control group did not receive ANP. Hemodynamic and blood gas parameters, and urine volume were measured at baseline, 3 h, and 24 h after initiating the ANP infusion. Plasma ANP concentrations markedly (p