SYNTHESIS OF A NEW CHEMICALLY STABLE PROSTACYCLIN ANALOGUE WITH HIGH AND LONG-LASTING ACTIVITY

The chemically stable prostacyclin analogue (Z)-4, 5-didehydroisocarbacyclin analogue (6) has been synthesized. Compound 6 given intravenously or orally is very potent in inhibiting platelet aggregation.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1990/06/25, Vol.38(6), pp.1769-1771
Hauptverfasser:	ISEKI, Katsuhiko, KANAYAMA, Toshiji, HAYASI, Yosio, SHIBASAKI, Masakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Epoprostenol - analogs & derivatives Epoprostenol - chemical synthesis Epoprostenol - pharmacology Humans hypotensive effect In Vitro Techniques isocarbacyclin Male platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemical synthesis prostacyclin Rats
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Beschreibung
Zusammenfassung:	The chemically stable prostacyclin analogue (Z)-4, 5-didehydroisocarbacyclin analogue (6) has been synthesized. Compound 6 given intravenously or orally is very potent in inhibiting platelet aggregation.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.38.1769