H-RAS 1 Minisatellite Rare Alleles: A Genetic Susceptibility and Prognostic Factor for Non-Hodgkin's Lymphoma

There has been a dramatic rise in non-Hodgkin's lymphoma (NHL) incidence and mortality throughout the world, prompting investigators to search for biomarkers indicating increased predisposition for NHL development. Calvo et al investigated whether rare H-RAS 1 proto-oncogene alleles could be es...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1998-07, Vol.90 (14), p.1095-1098
Hauptverfasser:	Calvo, Roser, Pifarré, Alex, Rosell, Rafael, Sánchez, José J, Monzoó, Mariano, Ribera, Josep M., Feliu, Evarist
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Alleles Biological and medical sciences Cancer Child Disease Susceptibility DNA Primers Female Genes Genes, ras - genetics Hematologic and hematopoietic diseases Heredity Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - genetics Male Medical research Medical sciences Middle Aged Minisatellite Repeats - genetics Prognosis
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Zusammenfassung:	There has been a dramatic rise in non-Hodgkin's lymphoma (NHL) incidence and mortality throughout the world, prompting investigators to search for biomarkers indicating increased predisposition for NHL development. Calvo et al investigated whether rare H-RAS 1 proto-oncogene alleles could be established as both a new inherited genetic marker of NHL susceptibility and a new independent prognostic factor for this disease.
ISSN:	0027-8874 1460-2105
DOI:	10.1093/jnci/90.14.1095