Nahocols and isonahocols, endothelin antagonists from the brown alga, Sargassum autumnale
Novel endothelin antagonists, nahocols A, A1, B, C, D1 and D2, and isonahocols D1 and D2, were isolated from the brown alga, Sargassum autumnale. Their structures were determined through detailed analysis of NMR spectra and chemical reactions. Nahocols have an aryl prenyl ether structure, which are...
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| Veröffentlicht in: | Phytochemistry (Oxford) 1998-07, Vol.48 (6), p.1003-1011 |
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| container_title | Phytochemistry (Oxford) |
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| creator | TSUCHIYA, N SATO, A HARUYAMA, H WATANABE, T IIJIMA, Y |
| description | Novel endothelin antagonists, nahocols A, A1, B, C, D1 and D2, and isonahocols D1 and D2, were isolated from the brown alga, Sargassum autumnale. Their structures were determined through detailed analysis of NMR spectra and chemical reactions. Nahocols have an aryl prenyl ether structure, which are speculated to be biogenetic precursors of the ubiquitous prenyl hydroquinones or prenyl benzoquinones in the plant and animal kingdoms. |
| doi_str_mv | 10.1016/S0031-9422(97)00476-7 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Phytochemistry (Oxford), 1998-07, Vol.48 (6), p.1003-1011 |
| issn | 0031-9422 1873-3700 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Chemical constitution Endothelin-1 - antagonists & inhibitors Fundamental and applied biological sciences. Psychology General pharmacology Marine Medical sciences Molecular Structure Phaeophyceae - chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - chemistry Phenols - pharmacology Plant physiology and development Sargassum autumnale Spectrum Analysis |
| title | Nahocols and isonahocols, endothelin antagonists from the brown alga, Sargassum autumnale |
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