Nahocols and isonahocols, endothelin antagonists from the brown alga, Sargassum autumnale

Nahocols and isonahocols, endothelin antagonists from the brown alga, Sargassum autumnale

Novel endothelin antagonists, nahocols A, A1, B, C, D1 and D2, and isonahocols D1 and D2, were isolated from the brown alga, Sargassum autumnale. Their structures were determined through detailed analysis of NMR spectra and chemical reactions. Nahocols have an aryl prenyl ether structure, which are...

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Veröffentlicht in:Phytochemistry (Oxford) 1998-07, Vol.48 (6), p.1003-1011
Hauptverfasser: TSUCHIYA, N, SATO, A, HARUYAMA, H, WATANABE, T, IIJIMA, Y
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Chemical constitution
Endothelin-1 - antagonists & inhibitors
Fundamental and applied biological sciences. Psychology
General pharmacology
Marine
Medical sciences
Molecular Structure
Phaeophyceae - chemistry
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - chemistry
Phenols - pharmacology
Plant physiology and development
Sargassum autumnale
Spectrum Analysis
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Zusammenfassung:Novel endothelin antagonists, nahocols A, A1, B, C, D1 and D2, and isonahocols D1 and D2, were isolated from the brown alga, Sargassum autumnale. Their structures were determined through detailed analysis of NMR spectra and chemical reactions. Nahocols have an aryl prenyl ether structure, which are speculated to be biogenetic precursors of the ubiquitous prenyl hydroquinones or prenyl benzoquinones in the plant and animal kingdoms.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(97)00476-7