Immunohistological detection of bovine viral diarrhoea virus antigen in the central nervous system of persistently infected cattle using monoclonal antibodies

In a total of 25 cattle persistently infected with bovine viral diarrhoea virus (BVDV) the distribution of viral antigens in the central nervous system was studied. Using a panel of monoclonal antibodies (anti pestivirus C16; anti cytophathic BVDV C38; anti cytopathic and non-cytopathic BVDV C42; an...

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Veröffentlicht in:	Veterinary microbiology 1990-06, Vol.23 (1), p.203-210
Hauptverfasser:	Hewicker, M., Wöhrmann, T., Fernandez, A., Trautwein, G., Liess, B., Moennig, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal ANTICORPS MONOCLONAL ANTICUERPOS MONOCLONALES Antigens, Viral - analysis Biological and medical sciences BOVIN Bovine Virus Diarrhea-Mucosal Disease - microbiology CATTLE Cattle Diseases - microbiology Central Nervous System - microbiology Cerebral Cortex - microbiology DIARREA Diarrhea Viruses, Bovine Viral - immunology Diarrhea Viruses, Bovine Viral - isolation & purification DIARRHEE DIARRHOEA Experimental viral diseases and models Frozen Sections GANADO BOVINO Hippocampus - microbiology IDENTIFICACION IDENTIFICATION Immunoenzyme Techniques Immunohistochemistry Infectious diseases Medical sciences MONOCLONAL ANTIBODIES Neurons - microbiology PESTIVIRUS Pestivirus - isolation & purification Viral diseases
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Zusammenfassung:	In a total of 25 cattle persistently infected with bovine viral diarrhoea virus (BVDV) the distribution of viral antigens in the central nervous system was studied. Using a panel of monoclonal antibodies (anti pestivirus C16; anti cytophathic BVDV C38; anti cytopathic and non-cytopathic BVDV C42; anti gp53 BVDV CA-1 and CA-3) and the indirect immunoperoxidase technique, BVDV antigen was located exclusively in neurons. Predilection sites for viral persistence were cerebral cortex and hippocampus. Morphological cellular alterations were not seen. Reactive perivascular lymphocytic infiltrations were occasional findings.
ISSN:	0378-1135 1873-2542
DOI:	10.1016/0378-1135(90)90150-T