Interplay of somatostatin and growth hormone-releasing hormone in genesis of episodic growth hormone secretion

The secretion of growth hormone (GH) is markedly pulsatile in nature in both man and experimental animals. Exensive evidence indicates that the episodic pattern of GH release from the pituitary gland is generated by an esquisite interplay between two hypothalamic neuropeptides, the stimulatory GH-re...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 1990-09, Vol.39 (9), p.35-39
Hauptverfasser:	Tannenbaum, Gloria Shaffer, Painson, Jean-Claude, Lapointe, Martine, Gurd, Wendy, McCarthy, G.Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Growth Hormone - blood Growth Hormone-Releasing Hormone - physiology Hormones and neuropeptides. Regulation Humans Hypothalamus - drug effects Hypothalamus - metabolism Hypothalamus. Hypophysis. Epiphysis. Urophysis Pituitary Gland - drug effects Pituitary Gland - metabolism Somatostatin - physiology Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	The secretion of growth hormone (GH) is markedly pulsatile in nature in both man and experimental animals. Exensive evidence indicates that the episodic pattern of GH release from the pituitary gland is generated by an esquisite interplay between two hypothalamic neuropeptides, the stimulatory GH-releasing hormone (GRF) and the inhibitory hormone, somatostatin (SRIF). This report will focus on the physiological significance of the SRIF/GRF interaction in genesis of episodic GH secretion.
ISSN:	0026-0495 1532-8600
DOI:	10.1016/0026-0495(90)90206-R