GBR 12909 reverses the SCH 23390 inhibition of rewarding effects of brain stimulation

Curve-shift was used to test the effect of SCH 23390, a dopamine D 1 receptor antagonist, and GBR-12909, a selective dopamine uptake blocker, on self-stimulation behavior. GBR 12909 (8 mg/kg) produced a significant decrease in self-stimulation threshold when administered alone, and reversed the incr...

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Veröffentlicht in:	European journal of pharmacology 1990-06, Vol.182 (1), p.181-184
Hauptverfasser:	Rompré, Pierre-Paul, Bauco, Pasqualino
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - antagonists & inhibitors Behavior, Animal - drug effects Benzazepines - antagonists & inhibitors Brain - physiology Dopamine Electric Stimulation GBR 12909 Male Neurotransmitter Uptake Inhibitors - pharmacology Piperazines - pharmacology Rats Reward SCH 23390 Self Stimulation - drug effects
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Zusammenfassung:	Curve-shift was used to test the effect of SCH 23390, a dopamine D 1 receptor antagonist, and GBR-12909, a selective dopamine uptake blocker, on self-stimulation behavior. GBR 12909 (8 mg/kg) produced a significant decrease in self-stimulation threshold when administered alone, and reversed the increase in threshold produced by SCH 23390 (0.08 mg/kg). The reversal of the SCH 23390 effect by GBR 12909 suggests that the inhibition of self-stimulation produced by SCH 23390 is due to blockade of dopamine receptors.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(90)90510-D