New insights into heparin-induced FGF oligomerization

New insights into heparin-induced FGF oligomerization

Fibroblast growth factors (FGFs) play important roles in a variety of developmental processes in mammals. The dependence of their activity on heparin binding has been a puzzle that, in recent years, has been the subject of active investigation. Recent structural analyses on complexes of FGFs with he...

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Veröffentlicht in:Nature Structural Biology 1998-07, Vol.5 (7), p.527-530
Hauptverfasser: Waksman, Gabriel, Herr, Andrew B
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biochemistry
Biological Microscopy
Biomedical and Life Sciences
Dimerization
Fibroblast Growth Factors - chemistry
Heparin - chemistry
Life Sciences
Mammals
Membrane Biology
news-and-views
Protein Conformation
Protein Structure
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Beschreibung
Zusammenfassung:Fibroblast growth factors (FGFs) play important roles in a variety of developmental processes in mammals. The dependence of their activity on heparin binding has been a puzzle that, in recent years, has been the subject of active investigation. Recent structural analyses on complexes of FGFs with heparin fragments or heparin analogs have unveiled the extreme complexity of these systems.
ISSN:1072-8368
2331-365X
1545-9985
DOI:10.1038/778