The control over the new obtaining procedeum of indomethacin
The synthesis of the indomethacin (1H-indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl) was achieved through a new method, which reduces some stages from the previous methods. Both the structure of the finished product and the structures of the intermediaries were investigated by chromat...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 1998-07, Vol.17 (3), p.409-413 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Rusu, D Cimpoiu, C Hodişan, T |
| description | The synthesis of the indomethacin (1H-indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl) was achieved through a new method, which reduces some stages from the previous methods. Both the structure of the finished product and the structures of the intermediaries were investigated by chromatographic methods (TLC, chromatography on column, GC-MSD) and spectroscopic methods (UV, IR, 1H-NMR,
13C-NMR). The chromatographic and spectroscopic studies proved that these had a special analytical value and they serve to control synthesis and to identify the compounds in all the stages of the process. |
| doi_str_mv | 10.1016/S0731-7085(97)00209-4 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 1998-07, Vol.17 (3), p.409-413 |
| issn | 0731-7085 1873-264X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79995496 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Analytical control Biological and medical sciences Chromatographic methods Chromatography - methods Gas Chromatography-Mass Spectrometry General pharmacology Indomethacin - analysis Indomethacin - chemical synthesis Indomethacin - chemistry Medical sciences Pharmacology. Drug treatments Spectroscopic methods Spectrum Analysis - methods Synthesis of the indomethacin |
| title | The control over the new obtaining procedeum of indomethacin |
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