The control over the new obtaining procedeum of indomethacin

The synthesis of the indomethacin (1H-indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl) was achieved through a new method, which reduces some stages from the previous methods. Both the structure of the finished product and the structures of the intermediaries were investigated by chromatographic methods (TLC, chromatography on column, GC-MSD) and spectroscopic methods (UV, IR, 1H-NMR, 13C-NMR). The chromatographic and spectroscopic studies proved that these had a special analytical value and they serve to control synthesis and to identify the compounds in all the stages of the process.