EPR and DNP Properties of Certain Novel Single Electron Contrast Agents Intended for Oximetric Imaging
Parameters of relevance to oximetry with Overhauser magnetic resonance imaging (OMRI) have been measured for three single electron contrast agents of the triphenylmethyl type. The single electron contrast agents are stable and water soluble. Magnetic resonance properties of the agents have been exam...
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| Veröffentlicht in: | Journal of magnetic resonance (1997) 1998-07, Vol.133 (1), p.1-12 |
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| container_title | Journal of magnetic resonance (1997) |
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| creator | Ardenkjær-Larsen, J.H. Laursen, I Leunbach, I. Ehnholm, G. Wistrand, L.-G. Petersson, J.S. Golman, K. |
| description | Parameters of relevance to oximetry with Overhauser magnetic resonance imaging (OMRI) have been measured for three single electron contrast agents of the triphenylmethyl type. The single electron contrast agents are stable and water soluble. Magnetic resonance properties of the agents have been examined with electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), and dynamic nuclear polarization (DNP) at 9.5 mT in water, isotonic saline, plasma, and blood at 23 and 37°C. The relaxivities of the agents are about 0.2–0.4 mM−1s−1and the DNP enhancements extrapolate close to the dipolar limit. The agents have a single, narrow EPR line, which is analyzed as a Voigt function. The linewidth is measured as a function of the agent concentration and the oxygen concentration. The concentration broadenings are about 1–3 μT/mM and the Lorentzian linewidths at infinite dilution are less than 1 μT in water at room temperature. The longitudinal electron spin relaxation rate is calculated from the DNP enhancement curves. The oxygen broadening in water is about 50 μT/mM O2at 37°C. These agents have good properties for oximetry with OMRI. |
| doi_str_mv | 10.1006/jmre.1998.1438 |
| format | Article |
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The single electron contrast agents are stable and water soluble. Magnetic resonance properties of the agents have been examined with electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), and dynamic nuclear polarization (DNP) at 9.5 mT in water, isotonic saline, plasma, and blood at 23 and 37°C. The relaxivities of the agents are about 0.2–0.4 mM−1s−1and the DNP enhancements extrapolate close to the dipolar limit. The agents have a single, narrow EPR line, which is analyzed as a Voigt function. The linewidth is measured as a function of the agent concentration and the oxygen concentration. The concentration broadenings are about 1–3 μT/mM and the Lorentzian linewidths at infinite dilution are less than 1 μT in water at room temperature. The longitudinal electron spin relaxation rate is calculated from the DNP enhancement curves. The oxygen broadening in water is about 50 μT/mM O2at 37°C. These agents have good properties for oximetry with OMRI.</description><identifier>ISSN: 1090-7807</identifier><identifier>EISSN: 1096-0856</identifier><identifier>DOI: 10.1006/jmre.1998.1438</identifier><identifier>PMID: 9654463</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Algorithms ; Chemical Phenomena ; Chemistry, Physical ; contrast agents ; Contrast Media - chemistry ; DNP ; Electron Spin Resonance Spectroscopy ; Electrons ; EPR ; Humans ; Image Enhancement ; Isotonic Solutions ; Linear Models ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Models, Chemical ; MRI ; Oximetry ; Oxygen - chemistry ; Plasma ; Sodium Chloride ; Solubility ; Temperature ; Trityl Compounds - blood ; Trityl Compounds - chemistry ; Water</subject><ispartof>Journal of magnetic resonance (1997), 1998-07, Vol.133 (1), p.1-12</ispartof><rights>1998 Academic Press</rights><rights>Copyright 1998 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-1c94016e9dad89f8d430675a6b14156d961c4380407ea8ba8fd857f2e08b281a3</citedby><cites>FETCH-LOGICAL-c405t-1c94016e9dad89f8d430675a6b14156d961c4380407ea8ba8fd857f2e08b281a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/jmre.1998.1438$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9654463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ardenkjær-Larsen, J.H.</creatorcontrib><creatorcontrib>Laursen, I</creatorcontrib><creatorcontrib>Leunbach, I.</creatorcontrib><creatorcontrib>Ehnholm, G.</creatorcontrib><creatorcontrib>Wistrand, L.-G.</creatorcontrib><creatorcontrib>Petersson, J.S.</creatorcontrib><creatorcontrib>Golman, K.</creatorcontrib><title>EPR and DNP Properties of Certain Novel Single Electron Contrast Agents Intended for Oximetric Imaging</title><title>Journal of magnetic resonance (1997)</title><addtitle>J Magn Reson</addtitle><description>Parameters of relevance to oximetry with Overhauser magnetic resonance imaging (OMRI) have been measured for three single electron contrast agents of the triphenylmethyl type. The single electron contrast agents are stable and water soluble. Magnetic resonance properties of the agents have been examined with electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), and dynamic nuclear polarization (DNP) at 9.5 mT in water, isotonic saline, plasma, and blood at 23 and 37°C. The relaxivities of the agents are about 0.2–0.4 mM−1s−1and the DNP enhancements extrapolate close to the dipolar limit. The agents have a single, narrow EPR line, which is analyzed as a Voigt function. The linewidth is measured as a function of the agent concentration and the oxygen concentration. The concentration broadenings are about 1–3 μT/mM and the Lorentzian linewidths at infinite dilution are less than 1 μT in water at room temperature. The longitudinal electron spin relaxation rate is calculated from the DNP enhancement curves. The oxygen broadening in water is about 50 μT/mM O2at 37°C. These agents have good properties for oximetry with OMRI.</description><subject>Algorithms</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>contrast agents</subject><subject>Contrast Media - chemistry</subject><subject>DNP</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Electrons</subject><subject>EPR</subject><subject>Humans</subject><subject>Image Enhancement</subject><subject>Isotonic Solutions</subject><subject>Linear Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Models, Chemical</subject><subject>MRI</subject><subject>Oximetry</subject><subject>Oxygen - chemistry</subject><subject>Plasma</subject><subject>Sodium Chloride</subject><subject>Solubility</subject><subject>Temperature</subject><subject>Trityl Compounds - blood</subject><subject>Trityl Compounds - chemistry</subject><subject>Water</subject><issn>1090-7807</issn><issn>1096-0856</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFvGjEUhK0qESFpr71F8im3pc-w67WPEaUNEgooac-Wsd8io12b2iZq_31MQb319EZ6MyPNR8hnBhMGwL_sh4gTJqWYsHomPpAxA8krEA2_-quhagW0N-Q2pT0AY00LIzKSvKlrPhuTbrF5odpb-vV5QzcxHDBmh4mGjs6L1M7T5_CGPX11ftcjXfRocgyezoPPUadMH3foc6JLn9FbtLQLka5_uwFzdIYuB70ryY_kutN9wk-Xe0d-flv8mD9Vq_X35fxxVZkamlwxI2tgHKXVVshO2HoGvG0037KaNdxKzkxZCTW0qMVWi86Kpu2mCGI7FUzP7sjDufcQw68jpqwGlwz2vfYYjkm1UsqSb4pxcjaaGFKK2KlDdIOOfxQDdQKrTmDVCaw6gS2B-0vzcTug_We_kCx_cf5jmffmMKpkHHqD1sWCTNng_lf9DgRAhuA</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Ardenkjær-Larsen, J.H.</creator><creator>Laursen, I</creator><creator>Leunbach, I.</creator><creator>Ehnholm, G.</creator><creator>Wistrand, L.-G.</creator><creator>Petersson, J.S.</creator><creator>Golman, K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>EPR and DNP Properties of Certain Novel Single Electron Contrast Agents Intended for Oximetric Imaging</title><author>Ardenkjær-Larsen, J.H. ; Laursen, I ; Leunbach, I. ; Ehnholm, G. ; Wistrand, L.-G. ; Petersson, J.S. ; Golman, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-1c94016e9dad89f8d430675a6b14156d961c4380407ea8ba8fd857f2e08b281a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Algorithms</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>contrast agents</topic><topic>Contrast Media - chemistry</topic><topic>DNP</topic><topic>Electron Spin Resonance Spectroscopy</topic><topic>Electrons</topic><topic>EPR</topic><topic>Humans</topic><topic>Image Enhancement</topic><topic>Isotonic Solutions</topic><topic>Linear Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Models, Chemical</topic><topic>MRI</topic><topic>Oximetry</topic><topic>Oxygen - chemistry</topic><topic>Plasma</topic><topic>Sodium Chloride</topic><topic>Solubility</topic><topic>Temperature</topic><topic>Trityl Compounds - blood</topic><topic>Trityl Compounds - chemistry</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ardenkjær-Larsen, J.H.</creatorcontrib><creatorcontrib>Laursen, I</creatorcontrib><creatorcontrib>Leunbach, I.</creatorcontrib><creatorcontrib>Ehnholm, G.</creatorcontrib><creatorcontrib>Wistrand, L.-G.</creatorcontrib><creatorcontrib>Petersson, J.S.</creatorcontrib><creatorcontrib>Golman, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ardenkjær-Larsen, J.H.</au><au>Laursen, I</au><au>Leunbach, I.</au><au>Ehnholm, G.</au><au>Wistrand, L.-G.</au><au>Petersson, J.S.</au><au>Golman, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EPR and DNP Properties of Certain Novel Single Electron Contrast Agents Intended for Oximetric Imaging</atitle><jtitle>Journal of magnetic resonance (1997)</jtitle><addtitle>J Magn Reson</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>133</volume><issue>1</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1090-7807</issn><eissn>1096-0856</eissn><abstract>Parameters of relevance to oximetry with Overhauser magnetic resonance imaging (OMRI) have been measured for three single electron contrast agents of the triphenylmethyl type. The single electron contrast agents are stable and water soluble. Magnetic resonance properties of the agents have been examined with electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), and dynamic nuclear polarization (DNP) at 9.5 mT in water, isotonic saline, plasma, and blood at 23 and 37°C. The relaxivities of the agents are about 0.2–0.4 mM−1s−1and the DNP enhancements extrapolate close to the dipolar limit. The agents have a single, narrow EPR line, which is analyzed as a Voigt function. The linewidth is measured as a function of the agent concentration and the oxygen concentration. The concentration broadenings are about 1–3 μT/mM and the Lorentzian linewidths at infinite dilution are less than 1 μT in water at room temperature. The longitudinal electron spin relaxation rate is calculated from the DNP enhancement curves. The oxygen broadening in water is about 50 μT/mM O2at 37°C. These agents have good properties for oximetry with OMRI.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9654463</pmid><doi>10.1006/jmre.1998.1438</doi><tpages>12</tpages></addata></record> |
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| subjects | Algorithms Chemical Phenomena Chemistry, Physical contrast agents Contrast Media - chemistry DNP Electron Spin Resonance Spectroscopy Electrons EPR Humans Image Enhancement Isotonic Solutions Linear Models Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Models, Chemical MRI Oximetry Oxygen - chemistry Plasma Sodium Chloride Solubility Temperature Trityl Compounds - blood Trityl Compounds - chemistry Water |
| title | EPR and DNP Properties of Certain Novel Single Electron Contrast Agents Intended for Oximetric Imaging |
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