Transformation of polycythemia vera to ph‐positive chronic myelogenous leukemia

A patient with polycythemia vera (PV) developed chronic myelogenous leukemia (CML) 8 years after his initial presentation with erythrocytosis. The patient received a total of 3.5‐7 g of chlorambucil over an approximate period of 5 years. Transformation of PV to CML is very unusual; only three substa...

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Veröffentlicht in:	American journal of hematology 1990-10, Vol.35 (2), p.110-113
1. Verfasser:	Haq, Amin U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bloodletting Cell Transformation, Neoplastic Chlorambucil - therapeutic use CML Conversion Diseases of red blood cells Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - blood Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Leukocyte Count Male Medical sciences Middle Aged p. vera Platelet Count Polycythemia Vera - blood Polycythemia Vera - pathology Polycythemia Vera - therapy Polycythemias Spleen - pathology
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Zusammenfassung:	A patient with polycythemia vera (PV) developed chronic myelogenous leukemia (CML) 8 years after his initial presentation with erythrocytosis. The patient received a total of 3.5‐7 g of chlorambucil over an approximate period of 5 years. Transformation of PV to CML is very unusual; only three substantiated cases had been reported in literature until 1975, and none has been described since then. All patients received either 32P or chemotherapy for PV treatment, suggesting that irradiation and alkylating agents may have played a role in the transformation to CML.
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.2830350209