Cyfra 21-1 as a Marker of Lung Cancer

Cyfra 21-1 as a Marker of Lung Cancer

The utility of cytokeratin fragment (Cyfra) 21-1, a new tumor marker, was investigated in 100 patients with lung cancer. Sandwich enzyme immunoassay detected Cyfra 21-1 in the sera of 60% of patients. Sensitivity of this marker was especially high (86.4%) for squamous cell carcinoma, exceeding that...

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Veröffentlicht in:Kurume medical journal 1998/04/01, Vol.45(1), pp.7-9
Hauptverfasser: KINOSHITA, MASAHARU, WATANABE, HISASHI, ICHIKI, MASAO, SUMITA, SHINYA, OKUBO, YO, MATSUNAMI, MICHIYA, FURUNO, HIROAKI, SHIRAISHI, TSUNEAKI, RIKIMARU, TORU, OIZUMI, KOTARO
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm - blood
Biomarkers, Tumor - blood
Cyfra 21-1
Female
Humans
Keratin-19
Keratins
lung cancer
Lung Neoplasms - blood
Male
Middle Aged
Sensitivity and Specificity
squamous cell carcinoma
tumor marker
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Zusammenfassung:The utility of cytokeratin fragment (Cyfra) 21-1, a new tumor marker, was investigated in 100 patients with lung cancer. Sandwich enzyme immunoassay detected Cyfra 21-1 in the sera of 60% of patients. Sensitivity of this marker was especially high (86.4%) for squamous cell carcinoma, exceeding that of a similar marker, squamous cell carcinoma antigen (SCC, 54.5%). In contrast, sensitivity of Cyfra 21-1 was relatively low for adenocarcinoma (52.6%) and for small cell carcinoma (50%). We conclude that Cyfra 21-1 is of value in diagnosis of lung cancer, particularly squamous cell carcinoma.
ISSN:0023-5679
1881-2090
DOI:10.2739/kurumemedj.45.7