Translocation between chromosomes 8q24 and 14q11 in T-cell acute lymphoblastic leukemia

Cytogenetic study was performed on a patient with T-cell acute lymphoblastic leukemia (T-ALL). It revealed a chromosomal translocation between chromosome bands 8q24 and 14q11. 8q24 is known to encode the oncogene c- myc, while 14q11 encodes the genes for T-cell receptor-α (TCR-α) and T-cell receptor...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1990-10, Vol.49 (1), p.69-74
Hauptverfasser:	Inaba, Tohru, Murakami, Satoshi, Oku, Nariaki, Itoh, Kunihiko, Ura, Yasuaki, Nakanishi, Shinobu, Shimazaki, Chihiro, Nishio, Akira, Nakagawa, Masao, Fujita, Naohisa, Nishigaki, Hikari, Taniwaki, Masafumi, Misawa, Shinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Chromosome Banding Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 8 DNA Probes Genetic Markers Hematologic and hematopoietic diseases Humans Karyotyping Leukemia-Lymphoma, Adult T-Cell - genetics Male Medical sciences Nucleic Acid Hybridization Proto-Oncogenes Receptors, Antigen, T-Cell - genetics Translocation, Genetic
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Zusammenfassung:	Cytogenetic study was performed on a patient with T-cell acute lymphoblastic leukemia (T-ALL). It revealed a chromosomal translocation between chromosome bands 8q24 and 14q11. 8q24 is known to encode the oncogene c- myc, while 14q11 encodes the genes for T-cell receptor-α (TCR-α) and T-cell receptor-δ (TCR-δ). Therefore, this chromosomal translocation t(8;14) (q24;q11) seemed to be unique and specific to T-cell malignancy.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(90)90165-7