ACTH Stimulation Tests and Plasma Dehydroepiandrosterone Sulfate Levels in Women with Hirsutism

HIRSUTISM is one of the clinical manifestations of increased circulating levels of androgens in women. The increase in the androgen levels may be due to exogenous sources, increased adrenal or ovarian secretion, or increased peripheral conversion of weak androgenic hormones such as dehydroepiandrosterone (DHEA) or androstenedione to more potent androgens. 1 Distinguishing among the causes of androgen excess may be difficult, but it is important because appropriate treatment depends on the diagnosis of the underlying disorder. DHEA sulfate is an easily measured, slowly metabolized steroid conjugate that is produced primarily by the adrenal glands. 2 3 4 Measurements of this hormone should therefore be . . .