Effects of gangliosides on the methionine uptake in crushed sciatic nerves of rats with alloxan diabetes

Effect of gangliosides on the transmembrane transport of methionine in crushed sciatic nerves was studied in alloxan diabetic and control rats until the 4th day after nerve crushing. Methionine uptake rate decreases while time passes after injury in both control and diabetic rats, but the decrement...

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Veröffentlicht in:	Neuroscience letters 1990-07, Vol.114 (2), p.220-224
Hauptverfasser:	Benech, C., Sotelo, J.R., Martinez, R., Correa-Luna, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport - drug effects Diabetes Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Fundamental and applied biological sciences. Psychology Gangliosides Gangliosides - pharmacology Isolated neuron and nerve. Neuroglia Kinetics Male Methionine - metabolism Nerve Crush Neuropathy Peripheral nerves Rats Reference Values Sciatic Nerve - drug effects Sciatic Nerve - metabolism Sciatic Nerve - physiopathology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Effect of gangliosides on the transmembrane transport of methionine in crushed sciatic nerves was studied in alloxan diabetic and control rats until the 4th day after nerve crushing. Methionine uptake rate decreases while time passes after injury in both control and diabetic rats, but the decrement is greater in diabetic rats than in controls. Ganglioside treatment causes an enhancement on the transmembrane transport in both diabetic and control animals, but the effect in time was greater in diabetic rats than in controls.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(90)90075-K