C-2 Arylation of Piperidines through Directed Transition-Metal-Catalyzed sp3 CH Activation

C-2 Arylation of Piperidines through Directed Transition-Metal-Catalyzed sp3 CH Activation

All you need is an open vial! The direct α arylation of cyclic alkylamines (see scheme) requires an open vial, as the hydrogen atom involved in the C(sp3)H‐activation process is ultimately released as hydrogen gas. Reports on the formation of hydrogen gas in direct transition‐metal‐catalyzed functi...

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Veröffentlicht in:Chemistry : a European journal 2010-11, Vol.16 (44), p.13063-13067
Hauptverfasser: Prokopcová, Hana, Bergman, Sheba D., Aelvoet, Karel, Smout, Veerle, Herrebout, Wouter, Van der Veken, Benjamin, Meerpoel, Lieven, Maes, Bert U. W.
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
CH activation
homogeneous catalysis
hydrogen
Molecular Structure
piperidines
Piperidines - chemistry
ruthenium
Ruthenium - chemistry
Stereoisomerism
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Zusammenfassung:All you need is an open vial! The direct α arylation of cyclic alkylamines (see scheme) requires an open vial, as the hydrogen atom involved in the C(sp3)H‐activation process is ultimately released as hydrogen gas. Reports on the formation of hydrogen gas in direct transition‐metal‐catalyzed functionalizations are still rare. Open‐vial reactions proved crucial to this direct arylation procedure as, upon sealing, catalyst deactivation occurs.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201001887