Molecular cloning and characterization of a novel dopamine receptor (D 3 ) as a target for neuroleptics

A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D 1 or D 2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D 3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional...

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Veröffentlicht in:	Nature (London) 1990-09, Vol.347 (6289), p.146-151
Hauptverfasser:	Sokoloff, Pierre, Giros, Bruno, Martres, Marie-Pascale, Bouthenet, Marie-Louise, Schwartz, Jean-Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antipsychotic Agents - pharmacology Antipsychotics Basal ganglia Base Sequence Biochemistry Biological and medical sciences Brain Brain Chemistry Cell Line Central nervous system diseases Cloning Cloning, Molecular Cricetinae DNA - genetics DNA Restriction Enzymes Dopamine Dopamine - metabolism Dopamine D2 receptors Dopamine D3 receptors Drug development Drugs Fundamental and applied biological sciences. Psychology Genes. Genome Guanylyl Imidodiphosphate - pharmacology Humanities and Social Sciences Hybridization Kidneys Medical research Molecular and cellular biology Molecular genetics Molecular Sequence Data Movement disorders multidisciplinary Nervous system Neurosciences Nucleic Acid Hybridization Parkinson's disease Pharmacology Polymerase Chain Reaction Proteins Psychiatry Psychopharmacology Psychotropic drugs Rats Receptors Receptors, Dopamine - drug effects Receptors, Dopamine - genetics Receptors, Dopamine - physiology Receptors, Dopamine D1 Receptors, Dopamine D2 Receptors, Dopamine D3 RNA, Messenger - analysis Science Science (multidisciplinary) Sequence Homology, Nucleic Acid Signs and symptoms Tissue Distribution
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Beschreibung
Zusammenfassung:	A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D 1 or D 2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D 3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D 2 receptors.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/347146a0