Continuous-flow synthesis of vitamin D3

Continuous-flow synthesis of vitamin D3

A highly efficient, two-stage, continuous-flow synthesis of vitamin D(3) from provitamin D(3) was achieved. The developed method afforded the desired product in high yield (HPLC-UV: 60%, isolated: 32%) and required neither intermediate purification nor high-dilution conditions.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2010-12, Vol.46 (46), p.8722-8724
Hauptverfasser: Fuse, Shinichiro, Tanabe, Nobutake, Yoshida, Masahito, Yoshida, Hayato, Doi, Takayuki, Takahashi, Takashi
Format: Artikel
Sprache:eng
Schlagworte:
Cholecalciferol - chemical synthesis
Cholecalciferol - chemistry
Chromatography, High Pressure Liquid - methods
Dehydrocholesterols - chemistry
Ultraviolet Rays
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Beschreibung
Zusammenfassung:A highly efficient, two-stage, continuous-flow synthesis of vitamin D(3) from provitamin D(3) was achieved. The developed method afforded the desired product in high yield (HPLC-UV: 60%, isolated: 32%) and required neither intermediate purification nor high-dilution conditions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc02239j